Methyl 2-(chloromethyl)oxazole-4-carboxylate → HCID 89767064, compound

HRID 1752516Notes

Reaction equation

HRID 1752516 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2S[CH:25]=[C:26]([C:28]([O:30][CH3:31])=[O:29])[N:27]=2)[CH2:18][CH2:17]1)=[O:13].ClCC1[O:35]C=C(C(OC)=O)N=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2[O:35][CH:25]=[C:26]([C:28]([O:30][CH3:31])=[O:29])[N:27]=2)[CH2:18][CH2:17]1)=[O:13]

Participants

3

Reactant 2

HCID 2763199Methyl 2-(chloromethyl)oxazole-4-carboxylateHCID 89767420HCID 89767420, compound

Product 1

HCID 89767064HCID 89767064, compound

Procedure

Methyl 2-{[4-({[(5-methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}-1,3-oxazole-4-carboxylate 9 was prepared, according to the procedure described for compound 7, using methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate. Yield: 410 mg, 45%.

Sources & evidence

ORD record
ord-df910b73ae4c4c6a8eb14a84c0d035ba
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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