HCID 89767064, compound → 2-{[4-({[(5-Methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}-1,3-oxazole-4-carboxylic acid hydrate

HRID 1752517Notes

Reaction equation

HRID 1752517 reaction equation
C[O:2]C1C=C2C(=CC=1)NN=C2C(NCC1CCN(CC2SC=C(C(O)=O)N=2)CC1)=O.[CH3:31][O:32][C:33]1[CH:34]=[C:35]2[C:39](=[CH:40][CH:41]=1)[NH:38][N:37]=[C:36]2[C:42]([NH:44][CH2:45][CH:46]1[CH2:51][CH2:50][N:49]([CH2:52][C:53]2[O:54][CH:55]=[C:56]([C:58]([O:60]C)=[O:59])[N:57]=2)[CH2:48][CH2:47]1)=[O:43]>>[OH2:2].[CH3:31][O:32][C:33]1[CH:34]=[C:35]2[C:39](=[CH:40][CH:41]=1)[NH:38][N:37]=[C:36]2[C:42]([NH:44][CH2:45][CH:46]1[CH2:51][CH2:50][N:49]([CH2:52][C:53]2[O:54][CH:55]=[C:56]([C:58]([OH:60])=[O:59])[N:57]=2)[CH2:48][CH2:47]1)=[O:43]

Participants

3

Reactant 2

HCID 89767064HCID 89767064, compoundHCID 89767207HCID 89767207, compound

Product 1

HCID 897671772-{[4-({[(5-Methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}-1,3-oxazole-4-carboxylic acid hydrate

Procedure

2-{[4-({[(5-Methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}-1,3-oxazole-4-carboxylic acid hydrate 10 was prepared, according to the procedure described for compound 8, starting from compound 9. Yield: 238 mg, 82%.

Sources & evidence

ORD record
ord-01de046755bb4f5f8284c6bb9b57a127
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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