Ethyl 4-(chloromethyl)-1,3-thiazole-2-carboxylate → HCID 89767659, compound

HRID 1752520Notes

Reaction equation

HRID 1752520 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19](CC2SC=C(C(OC)=O)N=2)[CH2:18][CH2:17]1)=[O:13].Cl[CH2:33][C:34]1[N:35]=[C:36]([C:39]([O:41][CH2:42][CH3:43])=[O:40])[S:37][CH:38]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:33][C:34]2[N:35]=[C:36]([C:39]([O:41][CH2:42][CH3:43])=[O:40])[S:37][CH:38]=2)[CH2:18][CH2:17]1)=[O:13]

Participants

3

Reactant 2

HCID 10822129Ethyl 4-(chloromethyl)-1,3-thiazole-2-carboxylateHCID 89767420HCID 89767420, compound

Product 1

HCID 89767659HCID 89767659, compound

Procedure

Ethyl 4-{[4-({[(5-methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}-1,3-thiazole-2-carboxylate 13 was prepared, according to the procedure described for compound 7, using ethyl 4-(chloromethyl)-1,3-thiazole-2-carboxylate. Yield: 45 mg, 11%.

Sources & evidence

ORD record
ord-7f1d7ce0304b43ed819805a0c4b225a7
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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