methyl 2-(chloromethyl)-3-furoate → HCID 89767472, compound

HRID 1752521Notes

Reaction equation

HRID 1752521 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2SC=C(C(OC)=O)N=2)[CH2:18][CH2:17]1)=[O:13].ClCC1[O:35][CH:36]=[CH:37][C:38]=1[C:39]([O:41][CH3:42])=[O:40]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2[O:35][CH:36]=[CH:37][C:38]=2[C:39]([O:41][CH3:42])=[O:40])[CH2:18][CH2:17]1)=[O:13]

Participants

3

Reactant 2

HCID 2049785methyl 2-(chloromethyl)-3-furoateHCID 89767420HCID 89767420, compound

Product 1

HCID 89767472HCID 89767472, compound

Procedure

Methyl 2-{[4-({[(5-methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}furan-3-carboxylate 14 was prepared, according to the procedure described for compound 7, using methyl 2-(chloromethyl)furan-3-carboxylate. Yield: 120 mg, 13%.

Sources & evidence

ORD record
ord-4544b491aa7940c88ab6169d27507440
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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