Ethyl 5-(chloromethyl)-2-furancarboxylate → HCID 89767382, compound

HRID 1752522Notes

Reaction equation

HRID 1752522 reaction equation
COC1C=C2C(=CC=1)NN=C2C(NCC1CCN(CC2SC=C(C(OC)=O)N=2)CC1)=O.Cl.[Br:33][C:34]1[CH:35]=[C:36]2[C:40](=[CH:41][CH:42]=1)[NH:39][N:38]=[C:37]2[C:43]([NH:45][CH2:46][CH:47]1[CH2:52][CH2:51][NH:50][CH2:49][CH2:48]1)=[O:44].Cl[CH2:54][C:55]1[O:59][C:58]([C:60]([O:62][CH2:63][CH3:64])=[O:61])=[CH:57][CH:56]=1>>[Br:33][C:34]1[CH:35]=[C:36]2[C:40](=[CH:41][CH:42]=1)[NH:39][N:38]=[C:37]2[C:43]([NH:45][CH2:46][CH:47]1[CH2:48][CH2:49][N:50]([CH2:54][C:55]2[O:59][C:58]([C:60]([O:62][CH2:63][CH3:64])=[O:61])=[CH:57][CH:56]=2)[CH2:51][CH2:52]1)=[O:44]

Participants

4

Reactant 3

HCID 263166Ethyl 5-(chloromethyl)-2-furancarboxylateHCID 89767022HCID 89767022, compoundHCID 89767420HCID 89767420, compound

Product 1

HCID 89767382HCID 89767382, compound

Procedure

Ethyl 5-{[4-({[(5-bromo-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}furan-2-carboxylate 15 was prepared, according to the procedure described for compound 7, from 11b and ethyl 5-(chloromethyl)furan-2-carboxylate. Yield: 300 mg, 62%.

Sources & evidence

ORD record
ord-5868261894634addae2106abed6775b2
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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