HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxypyridine-3-boronic acid → 5-({4-[({[5-(4-Methoxypyridin-3-yl)-1H-indazol-3-yl]carbonyl}amino)methyl]piperidin-1-yl}methyl)furan-2-carboxylic acid formate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxypyridine-3-boronic acid | HCID 2762556 | — |
| Reactant | HCID 89767382 | HCID 89767382 | — |
| Reactant | 2-({4-[({[5-(2,3-Difluorophenyl)-1H-indazol-3-yl]carbonyl}amino)methyl]piperidin-1-yl}methyl)-1,3-oxazole-4-carboxylic acid hydrate | HCID 89767635 | — |
| Product | 5-({4-[({[5-(4-Methoxypyridin-3-yl)-1H-indazol-3-yl]carbonyl}amino)methyl]piperidin-1-yl}methyl)furan-2-carboxylic acid formate | HCID 89767465 | — |
Reaction Steps
5-({4-[({[5-(4-Methoxypyridin-3-yl)-1H-indazol-3-yl]carbonyl}amino)methyl]piperidin-1-yl}methyl)furan-2-carboxylic acid formate 21 was prepared, according to the procedure described for compound 12, from compound 15 and (4-methoxypyridin-3-yl)boronic acid and using the following preparative HPLC parameters for the purification: channel A=CH3CN+0.1% formic acid; channel B=H2O+0.1% formic acid: flow=40 ml/min; gradient=2%-40% of eluent A in 15 minutes. Yield: 40 mg, 14%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09163013B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-5868dc5efffb4590817e422bcc510d00 |
| Source note | uspto-grants-2015_10 |