HCID 89767207, compound → 5-{[4-({[(5-Bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}furan-2-carboxylic acid

HRID 1752529Notes

Reaction equation

HRID 1752529 reaction equation
COC1C=C2C(=CC=1)NN=C2C(NCC1CCN(CC2SC=C(C(O)=O)N=2)CC1)=O.[Br:31][C:32]1[CH:33]=[C:34]2[C:38](=[CH:39][CH:40]=1)[NH:37][N:36]=[C:35]2[C:41]([NH:43][CH2:44][CH:45]1[CH2:50][CH2:49][N:48]([CH2:51][C:52]2[O:56][C:55]([C:57]([O:59]CC)=[O:58])=[CH:54][CH:53]=2)[CH2:47][CH2:46]1)=[O:42]>CCO>[Br:31][C:32]1[CH:33]=[C:34]2[C:38](=[CH:39][CH:40]=1)[NH:37][N:36]=[C:35]2[C:41]([NH:43][CH2:44][CH:45]1[CH2:50][CH2:49][N:48]([CH2:51][C:52]2[O:56][C:55]([C:57]([OH:59])=[O:58])=[CH:54][CH:53]=2)[CH2:47][CH2:46]1)=[O:42]

Participants

4

Reactant 2

HCID 89767207HCID 89767207, compoundHCID 89767382HCID 89767382, compound

Product 1

HCID 897672045-{[4-({[(5-Bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}furan-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-{[4-({[(5-Bromo-1H-indazol-3-yl)carbonyl]amino}methyl)piperidin-1-yl]methyl}furan-2-carboxylic acid 22 was prepared, according to the procedure described for compound 8, starting from compound 15 and using EtOH as solvent. Yield: 264 mg, 98%.

Sources & evidence

ORD record
ord-b9bdbbb1ba2d4a5ba45d35b0fb41424e
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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