Ethyl 5-(chloromethyl)-2-furancarboxylate → HCID 89767412, compound

HRID 1752530Notes

Reaction equation

HRID 1752530 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][C:23]2SC=C(C(OC)=O)N=2)[CH2:18][CH2:17]1)=[O:13].ClCC1[O:38][C:37]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[CH:36][CH:35]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[C:12]([NH:14][CH2:15][CH:16]1[CH2:17][CH2:18][N:19]([CH2:22][C:23]2[O:38][C:37]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[CH:36][CH:35]=2)[CH2:20][CH2:21]1)=[O:13]

Participants

3

Reactant 2

HCID 263166Ethyl 5-(chloromethyl)-2-furancarboxylateHCID 89767420HCID 89767420, compound

Product 1

HCID 89767412HCID 89767412, compound

Procedure

Ethyl 5-{[4-({[(5-methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}furan-2-carboxylate 23 was prepared, according to the procedure described for compound 7, starting from ethyl 5-(chloromethyl)furan-2-carboxylate. Yield: 290 mg, 71%.

Sources & evidence

ORD record
ord-a82569b2b3d9473388e0769bb14f46c9
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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