HCID 89767207, compound → 5-{[4-({[(5-Methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}furan-2-carboxylic acid

HRID 1752531Notes

Reaction equation

HRID 1752531 reaction equation
COC1C=C2C(=CC=1)NN=C2C(NCC1CCN(CC2SC=C(C(O)=O)N=2)CC1)=O.[CH3:31][O:32][C:33]1[CH:34]=[C:35]2[C:39](=[CH:40][CH:41]=1)[NH:38][N:37]=[C:36]2[C:42]([NH:44][CH2:45][CH:46]1[CH2:51][CH2:50][N:49]([CH2:52][C:53]2[O:57][C:56]([C:58]([O:60]CC)=[O:59])=[CH:55][CH:54]=2)[CH2:48][CH2:47]1)=[O:43]>CCO>[CH3:31][O:32][C:33]1[CH:34]=[C:35]2[C:39](=[CH:40][CH:41]=1)[NH:38][N:37]=[C:36]2[C:42]([NH:44][CH2:45][CH:46]1[CH2:51][CH2:50][N:49]([CH2:52][C:53]2[O:57][C:56]([C:58]([OH:60])=[O:59])=[CH:55][CH:54]=2)[CH2:48][CH2:47]1)=[O:43]

Participants

4

Reactant 2

HCID 89767207HCID 89767207, compoundHCID 89767412HCID 89767412, compound

Product 1

HCID 897670875-{[4-({[(5-Methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}furan-2-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-{[4-({[(5-Methoxy-1H-indazol-3-yl)carbonyl]amino}methyl) piperidin-1-yl]methyl}furan-2-carboxylic acid 24 was prepared, according to the procedure described for compound 8, starting from compound 23 and using EtOH as solvent. Yield: 64 mg, 84%.

Sources & evidence

ORD record
ord-7b3687eb0f88404fbdc2e92a45da58c8
Source dataset
uspto-grants-2015_10
Patent number
US09163013B2

Reaction notes

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