HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4'-nitroacetophenone → HCID 59396118, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4'-nitroacetophenone | HCID 66840 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | HCID 59396118 | HCID 59396118 | 100% |
Reaction Steps
To a solution of BOC-L-Proline (0.485 g, 2.25 mmol) and 2-Bromo-4′-nitro acetophenone (0.500 g, 2.05 mmol) in acetonitrile (20 mL) was added diisopropylethylamine (0.39 mL, 2.25 mmol) dropwise at ambient temperature. After stirred for four hours, the solution was poured into brine and extracted into ethyl acetate, dried over sodium sulfate, filtered, and the filtrate was concentrated to give a crude material that was used without purification (100% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09163017B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-0c7ed319b3054c128fefc6bd819af1dd |
| Source note | uspto-grants-2015_10 |