Potassium Carbonate → HCID 86295633, compound

Participants

Reaction Steps

K2CO3 (1.127 g, 8.16 mmol), Pd2(dba)3 (0.249 g, 0.272 mmol) and dicyclohexyl[2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]-phosphine (0.13 g, 0.272 mmol) were subsequently added to a suspension of 7-chloro-5-methyl-2-(2-quinolin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione (1 g, 2.72 mmol, see Example c1)) and thiomorpholine 1,1-dioxide (0.551 g, 4.08 mmol) in toluene (10 ml) and the mixture was stirred for 4 h under reflux. The solvent was removed and the resulting mixture was purified on a silica column (DCM/MeOH=50:1) to afford the title compound (0.8 g, 63% yield).

Provenance & Evidence