HCID 78210284, compound → HCID 86295636, compound

Participants

Reaction Steps

Zinc (0.375 g, 5.74 mmol) was added to a solution of 5-methyl-7-morpholin-4-yl-2-(2-quinolin-2-yl-ethyl)-5H-pyrrolo[3,4-c]pyridine-1,3,6-trione (0.8 g, 1.91 mmol, see Example 1) in acetic acid (15 ml) and the reaction was stirred for 8 h under reflux. The solvent was removed and the resulting mixture was purified via preparative HPLC (Waters system, eluent: MeCN/ammonium acetate buffer (gradient: 10:90 to 80:20 over 20 min), column: Hanbon Benetnach C18, 10 μm, 21.2×250 mm) to afford the title compound (47 mg, 6% yield).

Provenance & Evidence