Ethanol → HCID 86295842, compound

Participants

Reaction Steps

Nickel (7.56 mg, 0.129 mmol) was added rapidly to a mixture of 5-methyl-7-morpholin-4-yl-(2-quinolin-2-yl-ethyl)-1,6-dioxo-5H-pyrrolo[3,4-c]pyridine-3-thione (0.56 g, 1.289 mmol, see Example 9.1) in EtOH (20 ml)/THF (5 ml). The mixture was allowed to stir under a hydrogen atmosphere (at a pressure of about 35 psi) at r.t. for about 16 h. The solvent was removed and the resulting mixture was purified via preparative HPLC (System: Isco Combi Flash Companion XL, eluent: MeCN/ammonium acetate buffer (gradient: 0:100 to 60:40 over 20 min), column: C-18, 21.2×250 mm) to afford the title compound (127 mg, 24.36% yield).

Provenance & Evidence