4-Fluorophenylboronic acid → 7-(4-Fluoro-phenyl)-5-methyl-2-(2-quinolin-2-yl-ethyl)-3,5-dihydro-2H-pyrrolo[3,4-c]pyridine-1,6-dione

HRID 1752631Notes

Reaction equation

HRID 1752631 reaction equation
Cl[C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]2[CH2:10][N:11]([CH2:14][CH2:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:17]=3)[C:12](=[O:13])[C:3]=12.[F:26][C:27]1[CH:32]=[CH:31][C:30](B(O)O)=[CH:29][CH:28]=1>>[F:26][C:27]1[CH:32]=[CH:31][C:30]([C:2]2[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]3[CH2:10][N:11]([CH2:14][CH2:15][C:16]4[CH:25]=[CH:24][C:23]5[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=5)[N:17]=4)[C:12](=[O:13])[C:3]=23)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 734247287-Chloro-5-methyl-2-(2-(quinolin-2-YL)ethyl)-2,3-dihydro-1H-pyrrolo[3,4-C]pyridine-1,6(5H)-dione

Product 1

HCID 862962787-(4-Fluoro-phenyl)-5-methyl-2-(2-quinolin-2-yl-ethyl)-3,5-dihydro-2H-pyrrolo[3,4-c]pyridine-1,6-dione

Procedure

The title compound was prepared in analogy to the process of Example 13 starting from 7-chloro-5-methyl-2-(2-quinolin-2-yl-ethyl)-3,5-dihydro-2H-pyrrolo[3,4-c]pyridine-1,6-dione (see Example c4)) and 4-fluorophenylboronic acid.

Sources & evidence

ORD record
ord-061f40a47920464486666cab09072127
Source dataset
uspto-grants-2015_10
Patent number
US09163019B2

Reaction notes

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