Hydrochloric Acid → HCID 86688739, compound

Participants

Reaction Steps

TEA (0.5 ml) and BOP (0.84 mmol) are added to a solution of acid 6g (0.7 mmol) in THF. After 1 h, the nitrate of (S)-2-amino-3-nitroxypropionic acid (1.5 mmol) is added and it is stirred for a further 2 h at RT. Then it is concentrated and the residue is dissolved in 10% K2CO3, then it is filtered. The solution thus obtained is acidified to pH 2 with 2N HCl and the precipitate obtained is filtered and dried; yield 80%, m.p. 109° C. FT-IR cm−1: 3300 (ν N—H), 1734 (ν C—O), 1640 (ν C—O), 1520 (δ N—H), 1278 (ν C—N), 1595 (νasO—NO2), 865 (νsO—NO2). 1H NMR (400 MHz, CDCl3): δ 7.70 (d, 2H), 7.30 (m, 4H), 7.23 (m, 2H), 6.73 (s broad, 1H), 6.50 (s, 1H), 4.70 (m, 1H), 4.20 (m, 2H), 3.54 (s, 2H), 3.01 (s, 3H), 2.07 (s, 3H).

Provenance & Evidence