m-Tolyl isocyanate → HCID 58329428, compound

HRID 1752738Notes

Reaction equation

HRID 1752738 reaction equation
C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH2:17][CH2:18][CH2:19][CH3:20])=[CH:13][CH:12]=[CH:11][C:10]=2[O:21][CH3:22])=[O:5])C.[N:23]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[CH:27]=1)=[C:24]=[O:25]>>[CH2:17]([N:16]1[C:15]2[C:14]3[CH:13]=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[C:9]=3[N:8]=[CH:7][C:6]=2[C:4](=[O:5])[N:23]([C:26]2[CH:27]=[C:28]([CH3:32])[CH:29]=[CH:30][CH:31]=2)[C:24]1=[O:25])[CH2:18][CH2:19][CH3:20]

Participants

3

Reactant 2

HCID 69303m-Tolyl isocyanateHCID 13038474HCID 13038474, compound

Product 1

HCID 58329428HCID 58329428, compoundYield 43.7%

Procedure

1-Butyl-7-methoxy-3-m-tolyl-1H-pyrimido[5,4-c]quinoline-2,4-dione (17 mg) was prepared from 4-butylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester (0.1 mmol) and 1-isocyanato-3-methyl-benzene (0.5 mmol) following general procedure C. LCMS: m/z 390 [M+1]+.

Sources & evidence

ORD record
ord-90c44da34a384fc0ba127e0ffb3d03d4
Source dataset
uspto-grants-2015_10
Patent number
US09163022B2

Reaction notes

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