5-Isocyanato-1,3-dioxaindane → HCID 44187418, compound

HRID 1752739Notes

Reaction equation

HRID 1752739 reaction equation
C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)=[CH:13][CH:12]=[CH:11][C:10]=2[O:22][CH3:23])=[O:5])C.[N:24]([C:27]1[CH:35]=[CH:34][C:30]2[O:31][CH2:32][O:33][C:29]=2[CH:28]=1)=[C:25]=[O:26]>>[O:31]1[C:30]2[CH:34]=[CH:35][C:27]([N:24]3[C:4](=[O:5])[C:6]4[CH:7]=[N:8][C:9]5[C:10]([O:22][CH3:23])=[CH:11][CH:12]=[CH:13][C:14]=5[C:15]=4[N:16]([CH:17]4[CH2:21][CH2:20][CH2:19][CH2:18]4)[C:25]3=[O:26])=[CH:28][C:29]=2[O:33][CH2:32]1

Participants

3

Reactant 2

HCID 52232135-Isocyanato-1,3-dioxaindaneHCID 672497184-Cyclopentylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester

Product 1

HCID 44187418HCID 44187418, compoundYield 76.5%

Procedure

3-Benzo[1,3]dioxol-5-yl-1-cyclopentyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione (33 mg) was prepared from 4-cyclopentylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester (0.1 mmol) and 5-isocyanato-benzo[1,3]dioxole (0.5 mmol) following general procedure C. LCMS: m/z 432 [M+1]+.

Sources & evidence

ORD record
ord-01a9b8d2c5544528802b62060782c121
Source dataset
uspto-grants-2015_10
Patent number
US09163022B2

Reaction notes

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