tetrahydrothiophene-3-sulfonyl chloride 1,1-dioxide → HCID 44187607, compound

HRID 1752749Notes

Reaction equation

HRID 1752749 reaction equation
Cl.Cl.[Cl:3][C:4]1[CH:5]=[C:6]([N:10]2[C:25](=[O:26])[C:14]3[CH:15]=[N:16][C:17]4[C:18]([O:23][CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=4[C:13]=3[N:12]([CH:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[C:11]2=[O:33])[CH:7]=[CH:8][CH:9]=1.[O:34]=[S:35]1(=[O:44])[CH2:39][CH2:38][CH:37]([S:40](Cl)(=[O:42])=[O:41])[CH2:36]1>>[Cl:3][C:4]1[CH:5]=[C:6]([N:10]2[C:25](=[O:26])[C:14]3[CH:15]=[N:16][C:17]4[C:18]([O:23][CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=4[C:13]=3[N:12]([CH:27]3[CH2:32][CH2:31][N:30]([S:40]([CH:37]4[CH2:38][CH2:39][S:35](=[O:44])(=[O:34])[CH2:36]4)(=[O:42])=[O:41])[CH2:29][CH2:28]3)[C:11]2=[O:33])[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 2772263tetrahydrothiophene-3-sulfonyl chloride 1,1-dioxideHCID 67248943HCID 67248943, compound

Product 1

HCID 44187607HCID 44187607, compound

Procedure

3-(3-Chloro-phenyl)-1-[1-(1,1-dioxo-tetrahydro-thiophene-3-sulfonyl)-piperidin-4-yl]-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione (51 mg) was prepared according to general procedure H from 3-(3-chloro-phenyl)-7-methoxy-1-piperidin-4-yl-1H-pyrimido[5,4-c]quinoline-2,4-dione.dihydrochloride (50 mg, 0.1 mmol) and 1,1-dioxo-tetrahydro-thiophene-3-sulfonyl chloride. LCMS: m/z 619 [M+1]+.

Sources & evidence

ORD record
ord-41efb194fcb447658c532b17daaff65a
Source dataset
uspto-grants-2015_10
Patent number
US09163022B2

Reaction notes

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