Benzene, 1-chloro-3-isocyanato- → HCID 58329474, compound

HRID 1752757Notes

Reaction equation

HRID 1752757 reaction equation
C(O[C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)=[CH:13][CH:12]=[CH:11][C:10]=2[O:23][CH3:24])=[O:5])C.[Cl:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([N:32]=[C:33]=[O:34])[CH:27]=1>>[Cl:25][C:26]1[CH:27]=[C:28]([N:32]2[C:4](=[O:5])[C:6]3[CH:7]=[N:8][C:9]4[C:10]([O:23][CH3:24])=[CH:11][CH:12]=[CH:13][C:14]=4[C:15]=3[N:16]([CH:17]3[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]3)[C:33]2=[O:34])[CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 17968Benzene, 1-chloro-3-isocyanato-HCID 3595066HCID 3595066, compound

Product 1

HCID 58329474HCID 58329474, compoundYield 68.8%

Procedure

3-(3-Chloro-phenyl)-1-cyclohexyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione (30 mg) was prepared from 4-cyclohexylamino-8-methoxy-quinoline-3-carboxylic acid ethyl ester (0.1 mmol) and 1-chloro-3-isocyanato-benzene (0.15 mmol) following general procedure C. LCMS: m/z 436 [M+1]+.

Sources & evidence

ORD record
ord-76dc62ece6c045138b6999535717979a
Source dataset
uspto-grants-2015_10
Patent number
US09163022B2

Reaction notes

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