Benzene, (2-bromoethoxy)- → 5,7-dimethyl-2-(2-phenoxyethylsulfanyl)-[1,2,4]triazolo[1,5-a]pyrimidine

HRID 1752779Notes

Reaction equation

HRID 1752779 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([SH:12])[N:11]=[C:4]2[N:3]=1.[CH:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21]Br)=[CH:15][CH:14]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([S:12][CH2:21][CH2:20][O:19][C:16]3[CH:17]=[CH:18][CH:13]=[CH:14][CH:15]=3)[N:11]=[C:4]2[N:3]=1

Participants

3

Reactant 2

HCID 68526Benzene, (2-bromoethoxy)-HCID 178426287HCID 178426287, compound

Product 1

HCID 37233125,7-dimethyl-2-(2-phenoxyethylsulfanyl)-[1,2,4]triazolo[1,5-a]pyrimidineYield 65%

Procedure

The title compound was prepared according to the experimentals described for Example 1 above from 5,7-dimethyl-[1,2,4]-triazolo[1,5-a]pyrimidine-2-thiol and b-bromophenetole in 65% yield; EM (calc.): 300.1; MS (ESI) m/e: 301.1 (M+H)+.

Sources & evidence

ORD record
ord-74279ab95dee49a8b27580976746c79d
Source dataset
uspto-grants-2015_10
Patent number
US09163027B2

Reaction notes

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