4,4-Dimethoxy-2-butanone → HCID 76684684, compound

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Reaction Steps

The title compound was prepared according to the experimentals described for Example 23 above from 3-{[2-(4-chlorophenoxy)ethyl]sulfanyl}-1H-1,2,4-triazol-5-amine and acetylacetaldehyde dimethyl acetal. The two regioisomers were separated by silica gel chromatography. 2-{[2-(4-chlorophenoxy)ethyl]sulfanyl}-5-methyl-[1,2,4]-triazolo[1,5-a]pyrimidine was obtained as off white crystals in 25% yield: EM (calc.): 320.0; MS (ESI) m/e: 321.0 (M+H)+. 1H NMR (CDCl3, 400 MHz) δ ppm: 8.53 (d, 1H, J=6.8 Hz), 7.22 (d, 2H), 6.90 (d, 1H, J=6.8 Hz), 6.87 (d, 2H), 4.34 (t, 2H), 3.63 (t, 2H), 2.70 (s, 3H).

Provenance & Evidence