Tryptophol → HCID 86719333, compound

HRID 1752825Notes

Reaction equation

HRID 1752825 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([SH:12])[N:11]=[C:4]2[N:3]=1.[NH:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([CH2:22][CH2:23]O)=[CH:14]1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([S:12][CH2:23][CH2:22][C:15]3[C:16]4[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=4)[NH:13][CH:14]=3)[N:11]=[C:4]2[N:3]=1

Participants

3

Reactant 2

HCID 10685TryptopholHCID 178426287HCID 178426287, compound

Product 1

HCID 86719333HCID 86719333, compoundYield 54%

Procedure

The title compound was prepared according to the experimentals described for Example 9 above from 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol and 2-(1H-indol-3-yl)ethanol in 54% yield; EM (calc.): 323.1; MS (ESI) m/e: 324.1 (M+H)+.

Sources & evidence

ORD record
ord-4a852ae2f92541fa92a1668cf6fc517a
Source dataset
uspto-grants-2015_10
Patent number
US09163027B2

Reaction notes

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