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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1752865Generated: October 28, 2026

Formaldehyde → 2-(3-Formyl-4-hydroxyphenyl)acetonitrile

https://huagongshe.com/reaction/1752865

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
Reactant4-Hydroxybenzyl cyanideHCID 26548—
Product2-(3-Formyl-4-hydroxyphenyl)acetonitrileHCID 8660769074.5%

Reaction Steps

Proceeding as in Reference 8, but substituting 4-hydroxyphenylacetonitrile (2.09 g, 15 mmol) and formaldehyde (3.6 g, 120 mmol) gave 3-formyl-4-hydroxyphenylacetonitrile (1.8 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09162986B2
Source datasetuspto-grants-2015_10
ORD IDord-1b289d2909a34a3d9339918f242971e5
Source noteuspto-grants-2015_10