1-(Chloromethoxy)-2-methoxyethane → Methyl 2-(3-bromo-5-formyl-4-((2-methoxyethoxy)methoxy)phenyl)acetate

HRID 1752878Notes

Reaction equation

HRID 1752878 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([O:14][CH3:15])=[O:13])[CH:5]=[C:6]([CH:9]=[O:10])[C:7]=1[OH:8].[CH3:16][O:17][CH2:18][CH2:19][O:20][CH2:21]Cl>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([O:14][CH3:15])=[O:13])[CH:5]=[C:6]([CH:9]=[O:10])[C:7]=1[O:8][CH2:16][O:17][CH2:18][CH2:19][O:20][CH3:21]

Participants

3

Reactant 2

HCID 775901-(Chloromethoxy)-2-methoxyethaneHCID 57198039Methyl 2-(3-bromo-5-formyl-4-hydroxyphenyl)acetate

Product 1

HCID 54469909Methyl 2-(3-bromo-5-formyl-4-((2-methoxyethoxy)methoxy)phenyl)acetate

Procedure

Proceeding as in Reference 12, but substituting methyl 3-bromo-5-formyl-4-hydroxyphenylacetate (27.32 g, 0.10 mole) and 2-methoxyethoxymethyl chloride (0.125 mol, 14.3 mL), gave methyl 3-bromo-5-formyl-4-(2-methoxyethoxymethoxy)-phenylacetate (31.4 g (87%).

Sources & evidence

ORD record
ord-c93809dabce04e769b9bf58bfd809c59
Source dataset
uspto-grants-2015_10
Patent number
US09162986B2

Reaction notes

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