反应详情

3-Bromo-2-methoxybenzaldehyde (28 g, 130 mmol) was combined with trimethylorthoformate (27.5 g, 28.6 mL, 260 mmol) in methanol (150 mL) and then chlorosulfonic acid (0.5 mL) was added dropwise to the mixture. The mixture was stirred for 3 hours and then concentrated by rotoevaporation. The residue was partitioned between ethyl ether and 5% aqueous sodium bicarbonate and the organic layer was separated, washed with water and brine, dried over sodium sulfate and concentrated to give 1-bromo-3-dimethoxymethyl-2-methoxybenzene (27.5 g).

1. concentrationconcentrated by rotoevaporation
2. customThe residue was partitioned between ethyl ether and 5% aqueous sodium bicarbonate
3. customthe organic layer was separated
4. washwashed with water and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated