HCID 131733649, compound → HCID 73672464, compound

Participants

Reaction Steps

To a solution of N-(5-{1-[2-(tert-Butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-1H-pyrrolo[3,2-c]pyridine-3-carbonyl}-pyridin-3-yl)-2-(5-chloro-pyridin-2-yl)-acetamide (Preparation 8, 45 mg, 0.077 mmol) in THF (3 mL), 4M dioxane-HCl (0.4 mL) was added and stirred at room temperature for 18 hours. The reaction was evaporated in vacuo and purified by column chromatography on silica gel (gradient of MeOH: DCM 0:100 to 3:100) to afford the title compound as a yellow solid in 69% yield, 25 mg.

Provenance & Evidence