(4-Chlorophenyl)acetic acid → 2-(4-chlorophenyl)-N-(5-{[7-fluoro-1-(1-hydroxypropan-2-yl)-1H-pyrrolo[3,2-c]pyridin-3-yl]carbonyl}pyridin-3-yl)acetamide

HRID 1753007Notes

Reaction equation

HRID 1753007 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:14]=[C:15]([C:19]([C:21]2[C:25]3[CH:26]=[N:27][CH:28]=[C:29]([F:30])[C:24]=3[N:23]([CH:31]([CH3:34])[CH2:32][OH:33])[CH:22]=2)=[O:20])[CH:16]=[N:17][CH:18]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([NH:12][C:13]2[CH:18]=[N:17][CH:16]=[C:15]([C:19]([C:21]3[C:25]4[CH:26]=[N:27][CH:28]=[C:29]([F:30])[C:24]=4[N:23]([CH:31]([CH3:34])[CH2:32][OH:33])[CH:22]=3)=[O:20])[CH:14]=2)=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 90093760HCID 90093760, compound

Product 1

HCID 1183412192-(4-chlorophenyl)-N-(5-{[7-fluoro-1-(1-hydroxypropan-2-yl)-1H-pyrrolo[3,2-c]pyridin-3-yl]carbonyl}pyridin-3-yl)acetamide

Procedure

Prepared according to Method M (Example 206) using 4-chlorophenylacetic acid and (5-aminopyridin-3-yl)[7-fluoro-1-(2-hydroxy-1-methylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone (Enantiomer 1, Preparation 26).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5e100f8f1f8c4d68bec691d697f662e5
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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