2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid → N-(5-{[7-fluoro-1-(1-hydroxypropan-2-yl)-1H-pyrrolo[3,2-c]pyridin-3-yl]carbonyl}pyridin-3-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetamide

Participants

Reaction Steps

Prepared according to Method M (Example 206) using [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid and (5-aminopyridin-3-yl)[7-fluoro-1-(2-hydroxy-1-methylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone (Enantiomer 2, Preparation 26). The residue was purified using preparative TLC eluting with 5% MeOH in EtOAc.

Provenance & Evidence