HCID 71756161, compound → HCID 118341211, compound

HRID 1753019Notes

Reaction equation

HRID 1753019 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:14]3[CH:15]=[N:16][CH:17]=[C:18]([F:19])[C:13]=3[N:12]([C:20]([CH3:31])([CH3:30])[CH2:21][O:22][Si](C(C)(C)C)(C)C)[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[CH:32]1([C:35]2[N:36]=[N:37][N:38]([CH2:40][C:41](O)=[O:42])[CH:39]=2)[CH2:34][CH2:33]1>>[CH:32]1([C:35]2[N:36]=[N:37][N:38]([CH2:40][C:41]([NH:1][C:2]3[CH:7]=[N:6][CH:5]=[C:4]([C:8]([C:10]4[C:14]5[CH:15]=[N:16][CH:17]=[C:18]([F:19])[C:13]=5[N:12]([C:20]([CH3:30])([CH3:31])[CH2:21][OH:22])[CH:11]=4)=[O:9])[CH:3]=3)=[O:42])[CH:39]=2)[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 71756161HCID 71756161, compoundHCID 90092825HCID 90092825, compound

Product 1

HCID 118341211HCID 118341211, compound

Procedure

Prepared according to Method 1 (Example 19) followed by Method Y (Example 1) using (5-Amino-pyridin-3-yl)-{1-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-7-fluoro-1H-pyrrolo[3,2-c]pyridin-3-yl}-methanone (Preparation 29) and (4-cyclopropyl-1H-1,2,3-triazol-1-yl)acetic acid (Preparation 94).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f49cd3815d9e48a19677957d99161f06
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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