HRID1753028

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2060883

[3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid

C6H5F3N2O2

结构：CC(C)(CO[Si](C)(C)C(C)(C)C)n1cc(C(=O)c2cc(N)ccn2)c2cnccc21

HCID90093653

未命名化合物

PRODUCTS

生成物

结构：CC(C)(CO[Si](C)(C)C(C)(C)C)n1cc(C(=O)c2cc(NC(=O)Cn3ccc(C(F)(F)F)n3)ccn2)c2cnccc21

HCID90093428

未命名化合物

PROCEDURE

实验过程

Prepared according to the method described for Method M (Example 206) using (4-aminopyridin-2-yl)[1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone (Preparation 27) and [3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (Preparation 74). The residue was purified using alumina eluting with 2% MeOH in DCM to afford the title compound.

WORKUP

后处理

customPrepared
customThe residue was purified

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e3c3c771572a46aaa2e19189237b9993
来源数据集: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09163021B2
来源说明: uspto-grants-2015_10

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([C:10]2[C:14]3[CH:15]=[N:16][CH:17]=[CH:18][C:13]=3[N:12]([C:19]([CH3:30])([CH3:29])[CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH:11]=2)=[O:9])[CH:3]=1.[F:31][C:32]([F:43])([F:42])[C:33]1[CH:37]=[CH:36][N:35]([CH2:38][C:39](O)=[O:40])[N:34]=1>>[Si:22]([O:21][CH2:20][C:19]([N:12]1[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[C:10]([C:8]([C:4]2[CH:3]=[C:2]([NH:1][C:39](=[O:40])[CH2:38][N:35]3[CH:36]=[CH:37][C:33]([C:32]([F:42])([F:31])[F:43])=[N:34]3)[CH:7]=[CH:6][N:5]=2)=[O:9])=[CH:11]1)([CH3:30])[CH3:29])([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:23])[CH3:24]