2-(4-Isopropyl-1H-1,2,3-triazol-1-yl)acetic acid → N-(5-{[1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]carbonyl}pyridin-3-yl)-2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(4-Isopropyl-1H-1,2,3-triazol-1-yl)acetic acid	HCID 18524442	—
Reactant	(5-aminopyridin-3-yl)[1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone	HCID 90093072	—
Product	N-(5-{[1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]carbonyl}pyridin-3-yl)-2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetamide	HCID 131733652	—

Reaction Steps

Prepared according to Method Z (Preparation 8) using (5-Amino-pyridin-3-yl)-{1-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-1H-pyrrolo[3,2-c]pyridin-3-yl}-methanone (Preparation 28) and (4-isopropyl-[1,2,3]triazol-1-yl)acetic acid. LCMS (5 minute run) Rt=3.32 minutes MS m/z 576 [M+H]+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09163021B2
Source dataset	uspto-grants-2015_10
ORD ID	ord-99cb3444d1324562bd3a28fb295d08ce
Source note	uspto-grants-2015_10