(5-Fluoropyridin-2-yl)acetic acid → HCID 90093664, compound

HRID 1753033Notes

Reaction equation

HRID 1753033 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:14]3[CH:15]=[N:16][CH:17]=[CH:18][C:13]=3[N:12]([C:19]([CH3:30])([CH3:29])[CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[F:31][C:32]1[CH:33]=[CH:34][C:35]([CH2:38][C:39](O)=[O:40])=[N:36][CH:37]=1>>[Si:22]([O:21][CH2:20][C:19]([N:12]1[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[C:10]([C:8]([C:4]2[CH:3]=[C:2]([NH:1][C:39](=[O:40])[CH2:38][C:35]3[CH:34]=[CH:33][C:32]([F:31])=[CH:37][N:36]=3)[CH:7]=[N:6][CH:5]=2)=[O:9])=[CH:11]1)([CH3:30])[CH3:29])([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 55267809(5-Fluoropyridin-2-yl)acetic acidHCID 90093072HCID 90093072, compound

Product 1

HCID 90093664HCID 90093664, compound

Procedure

Prepared according to Method Z (Preparation 8) using (5-Amino-pyridin-3-yl)-{1-[2-(tert-butyl-dimethyl-silanyloxy)-1,1-dimethyl-ethyl]-1H-pyrrolo[3,2-c]pyridin-3-yl}-methanone (Preparation 28) and (5-fluoropyridin-2-yl)acetic acid (Preparation 82).

Workup

  1. customPrepared
  2. customaccording to Method Z (Preparation 8)

Sources & evidence

ORD record
ord-1f975ee943ab4ab2b1ef1120a3b6247c
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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