(5-Chloropyridin-2-yl)acetic acid → HCID 90093909, compound

HRID 1753034Notes

Reaction equation

HRID 1753034 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([C:10]2[C:14]3[CH:15]=[N:16][CH:17]=[CH:18][C:13]=3[N:12]([CH:19]([CH3:29])[CH2:20][O:21][Si:22]([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:24])[CH3:23])[CH:11]=2)=[O:9])[CH:3]=1.[Cl:30][C:31]1[CH:32]=[CH:33][C:34]([CH2:37][C:38](O)=[O:39])=[N:35][CH:36]=1>>[Si:22]([O:21][CH2:20][CH:19]([N:12]1[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[C:10]([C:8]([C:4]2[CH:3]=[C:2]([NH:1][C:38](=[O:39])[CH2:37][C:34]3[CH:33]=[CH:32][C:31]([Cl:30])=[CH:36][N:35]=3)[CH:7]=[CH:6][N:5]=2)=[O:9])=[CH:11]1)[CH3:29])([C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 46737473(5-Chloropyridin-2-yl)acetic acidHCID 90092938(4-aminopyridin-2-yl)[1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone

Product 1

HCID 90093909HCID 90093909, compound

Procedure

Prepared according to Method Z (Preparation 8) using (4-aminopyridin-2-yl)[1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone (Preparation 30) and (5-chloropyridin-2-yl)acetic acid (Preparation 80).

Workup

  1. customPrepared
  2. customaccording to Method Z (Preparation 8)

Sources & evidence

ORD record
ord-76034d1f986346a782e110c765b324d6
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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