Trifluoroacetic acid → HCID 118341213, compound

Participants

Reaction Steps

To a solution of di-tert-butyl {5-[(1-isopropyl-1H-pyrrolo[3,2-c]pyridin-3-yl)carbonyl]-2-methoxypyridin-3-yl}imidodicarbonate (Preparation 32, 250 mg, 0.5 mmol) in DCM (2.5 mL) at 0° C. was added TFA (0.75 mL) dropwise and the reaction stirred warming to room temperature for 5 hours. The reaction was basified by the addition of saturated aqueous NaHCO3 solution and extracted into DCM (3×30 mL). The organic layers were combined, dried over sodium sulphate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 5% MeOH in DCM to afford the title compound.

Provenance & Evidence