Methyl 2-bromopropionate → HCID 90093829, compound

HRID 1753064Notes

Reaction equation

HRID 1753064 reaction equation
[CH3:1][O:2][C:3](=[O:7])[CH:4](Br)[CH3:5].[F:8][C:9]1[C:10]2[NH:17][CH:16]=[C:15]([I:18])[C:11]=2[CH:12]=[N:13][CH:14]=1>>[F:8][C:9]1[C:10]2[N:17]([CH:4]([CH3:5])[C:3]([O:2][CH3:1])=[O:7])[CH:16]=[C:15]([I:18])[C:11]=2[CH:12]=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 95576Methyl 2-bromopropionateHCID 534131647-Fluoro-3-iodo-1H-pyrrolo[3,2-c]pyridine

Product 1

HCID 90093829HCID 90093829, compound

Procedure

Prepared according to the method described for Preparation 45 using 2-bromo-propionic acid methyl ester and 7-fluoro-3-iodo-pyrrolo[3,2-c]pyridine (Preparation 61). Purified using silica gel column chromatography eluting with 0-5% MeOH in DCM.

Workup

  1. customPrepared
  2. customPurified
  3. washeluting with 0-5% MeOH in DCM

Sources & evidence

ORD record
ord-f334e73f76304ebd9486965e8aadea55
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

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