反应详情

To a solution of methyl 2-(3-iodo-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-methylpropanoate (Preparation 67, 10.8 g, 31.38 mmol) in EtOH (100 mL) was added sodium borohydride (2.37 g, 62.8 mmol) and the reaction stirred at room temperature for 5 hours. The reaction was quenched by the addition of water (100 mL) and the phases separated through a phase separation cartridge. The organic layer was concentrated in vacuo to afford and orange oil that was triturated with ether to afford an orange solid as the title compound (3.86 g, 39%).

1. customThe reaction was quenched by the addition of water (100 mL)
2. customthe phases separated through a phase separation cartridge
3. concentrationThe organic layer was concentrated in vacuo
4. customto afford
5. customorange oil that was triturated with ether