HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 118344726, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 22271444 | HCID 22271444 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 118344726 | HCID 118344726 | — |
Reaction Steps
To a solution of 5-[bis(tert-butoxycarbonyl)amino]-6-methoxynicotinic acid (Preparation 70, 500 mg, 1.358 mmol) and DIPEA (730 uL, 4.076 mmol) in DMF (4 mL) was added HATU (774 mg, 2.038 mmol) and N-methoxy-methylamine hydrochloride (198 mg, 2.038 mmol) and the reaction stirred at room temperature for 16 hours. The reaction was partitioned between saturated aqueous NaHCO3 solution and EtOAc, the organic layer collected, dried over sodium sulfate and concentrated in vacuo to afford the title compound that was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09163021B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-5aca984bcbbd4baea4b8a75c416b70bf |
| Source note | uspto-grants-2015_10 |