Trifluoroacetic acid → 2-[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid

Participants

Reaction Conditions

Reaction Steps

Trifluoroacetic acid (10 mL) was added to tert-butyl[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetate (Preparation 77, 1.3 g, 5.2 mmol) in dry DCM (10 mL) and the mixture was stirred for 18 hours at 25° C. Then the mixture was evaporated in vacuo and the residue was purified by trituration with diethyl ether:pentane (1:9, 2 mL) to afford the title compound as a white solid (79%, 800 mg).

Provenance & Evidence