Isopropyl iodide → ethyl 1-isopropyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

HRID 1753099Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[C:7]([C:11]([F:14])([F:13])[F:12])=[N:8][NH:9][CH:10]=1)=[O:5])[CH3:2].[CH:15](I)([CH3:17])[CH3:16]>>[CH2:1]([O:3][C:4]([C:6]1[C:7]([C:11]([F:13])([F:14])[F:12])=[N:8][N:9]([CH:15]([CH3:17])[CH3:16])[CH:10]=1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 178469923HCID 178469923, compound

Product 1

HCID 57574507ethyl 1-isopropyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Procedure

Prepared according to Preparation 45 using 3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid ethyl ester (Preparation 112) and isopropyl iodide. Taken directly on to the next step.

Workup

customPrepared

Sources & evidence

ORD record: ord-65ae1d02ac1a4e4094c5350023e85d1a
Source dataset: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09163021B2

Reaction notes

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