HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate | HCID 2737179 | — |
Reaction Steps
To a solution of ethyl 4,4,4-trifluoro-3-oxobutanoate (20 g, 108.63 mmol) in acetic anhydride (39 mL) was added triethylorthoformate (54.2 mL, 325.89 mmol) and the reaction heated to reflux for 18 hours. The reaction was cooled, concentrated in vacuo and used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09163021B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-c4d1ba12b2db4c698f4e8d65ad4744ba |
| Source note | uspto-grants-2015_10 |