Ethyl bromoacetate → HCID 90093751, compound

HRID 1753110Notes

Reaction equation

HRID 1753110 reaction equation
[CH:1]([C:4]1[NH:8][N:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:2].Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12]>>[CH2:14]([O:13][C:11](=[O:12])[CH2:10][N:8]1[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=[N:7]1)[CH3:15]

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 122513813-Isopropyl-1H-pyrazole

Product 1

HCID 90093751HCID 90093751, compoundYield 6%

Procedure

Prepared according to the method described for Preparation 75 using 5-isopropyl-1H-pyrazole and ethyl bromoacetate. The residue was purified using silica gel column chromatography eluting with 4:1 hexane:EtOAc. The title compound was isolated as the lower running minor product in 6% yield, and taken directly on to the next step.

Workup

  1. customPrepared
  2. customThe residue was purified
  3. washeluting with 4:1 hexane

Sources & evidence

ORD record
ord-d7ba6912db9b4940affd182c946499f4
Source dataset
uspto-grants-2015_10
Patent number
US09163021B2

Reaction notes

Loading…