1,3-Propanediamine → HCID 58406354, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 1-[2-(4-chlorophenyl)-2-oxoethyl]-1H-pyrrole-2-carboxylate (100 mg, 0.36 mmol) was mixed with propane-1,3-diamine (0.9 g, 12.14 mmol) in xylenes (2 mL) and the mixture heated in the microwave at 180° C. for 1 hour (monitored by LCMS). The mixture was concentrated in vacuo and purified by flash chromatography using 2 to 10% MeON in CH2Cl2, to give 11a-(4-chlorophenyl)-1,2,3,4,11,11a-hexahydro-6H-pyrrolo[1′,2′:4,5]pyrazino[1,2-a]pyrimidin-6-one (123) (11.5 mg, yield 10%).

Provenance & Evidence