Diethyl acetylenedicarboxylate → HCID 67371898, compound

Participants

Reaction Steps

Diethyl but-2-ynedioate (1.6 equivalents) was added to a stirred solution of crude tert-butyl 2-[2-(4-methoxyphenyl)-2-oxoethyl]hydrazinecarboxylate (2 g) in ethanol at 0° C. The reaction was monitored by LCMS. Upon completion, the reaction mixture was concentrated in vacuo to give crude diethyl 2-{2-(tert-butoxycarbonyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]hydrazinyl}but-2-enedioate (1.3 g). The material was carried through without purification. ESI-MI m/z [M+H]+ 451.

Provenance & Evidence