N-bromobutanimide → HCID 127264019, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 5-cyano-2-methoxy-3-methyl-pyridine (36) (0.25 g, 1.7 mmol) in CCl4 (10 mL) was added N-bromosuccinimide (346 mg, 1.7 mmol) and 2′,2-azobisisobutyronitrile (13.0 mg, 0.085 mmol). The reaction mixture was stirred at 80° C. for 1 h. The reaction mixture was filtered and the filtrate was concentrated to afford 5-(bromomethyl)-6-methoxy nicotinonitrile (37) as a yellow solid; (180 mg, 46.9%).

Provenance & Evidence