HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Reactant | 6-Aminoindole | HCID 256096 | — |
| Product | 2-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine | HCID 22060459 | — |
Reaction Steps
In a like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and 6-aminoindole were reacted to provide 2-chloro-5-fluoro-N4-[(1H)-indol-6-yl]-4-pyrimidineamine. LCMS: purity: 92%; MS (m/e): 263 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162989B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-412e0bdf5fdb47ce9b042226ac031109 |
| Source note | uspto-grants-2015_10 |