HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → 5-fluoro-N,N'-bis(4-methylphenyl)pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Product | 5-fluoro-N,N'-bis(4-methylphenyl)pyrimidine-2,4-diamine | HCID 22060989 | — |
Reaction Steps
In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 4-methylaniline were reacted to yield N2,N4-bis(4-methylphenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.73 (d, 1H, J=4.2 Hz), 7.43 (d, 2H, J=8.1 Hz), 7.36 (d, 2H, J=8.4 Hz), 7.14 (d, 2H, J=8.4 Hz), 7.10 (d, 2H, J=8.1 Hz), 2.39 (s, 3H), 2.35 (s, 3H); LCMS: ret. time: 25.81 min.; purity: 99.65%; MS (m/e): 309 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162989B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-18e891d5f1fe42fd875064e9fc9dedac |
| Source note | uspto-grants-2015_10 |