HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-2-carboxylic acid, 7-amino-, ethyl ester → N4-(3,5-dimethoxyphenyl)-N2-(2-ethoxycarbonylindol-7-yl)-5-fluoro-2,4-pyrimidinediamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-2-carboxylic acid, 7-amino-, ethyl ester | HCID 11138194 | — |
| Reactant | 2-chloro-N4-(3,5-dimethoxyphenyl)-5-fluoro-4-pyrimidineamine | HCID 22060694 | — |
| Product | N4-(3,5-dimethoxyphenyl)-N2-(2-ethoxycarbonylindol-7-yl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060274 | — |
Reaction Steps
In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine, the reaction of 2-chloro-N4-(3,5-dimethoxyphenyl)-5-fluoro-4-pyrimidineamine with 2-ethoxycarbonyl-7-aminoindole gave N4-(3,5-dimethoxyphenyl)-N2-(2-ethoxycarbonylindol-7-yl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 24.21 min.; purity: 91%; MS (m/e): 452 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09162989B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-5e911da70a4148bb817ff8bec0d3416c |
| Source note | uspto-grants-2015_10 |