Dimethylformamide → HCID 117666967, compound

Participants

Reaction Steps

A solution was obtained by combining 20.2 g of 4-hydroxyphenyl phenyl sulfide which had been synthesized according to the well-known formulation, 15.3 g of 2,2,2-trifluoroethyl p-toluenesulfonate, 12.4 g of potassium carbonate, and 80 g of DMF. The solution was aged at 100° C. for 16 hours. The aged solution was cooled to room temperature, to which 50 g of water was added to quench the reaction. To the solution, 200 g of toluene was added for extraction. The organic layer was separated, and washed with 100 g of 5 wt % sodium hydroxide aqueous solution and water in sequence. On subsequent concentration in vacuum, 16.4 g of the target compound, phenyl 4-(2,2,2-trifluoroethoxy)phenyl sulfide was obtained as oily matter. Yield 96%.

Provenance & Evidence