Hydrogen Peroxide → HCID 117666905, compound

Participants

Reaction Steps

In 100 g of acetic acid was dissolved 13.8 g of 4-cyclopentyloxyphenyl phenyl sulfide obtained in Synthesis Example 1-25. While the solution was maintained at an internal temperature of 30° C., 4.8 g of 35 wt % aqueous hydrogen peroxide was added dropwise. The reaction solution was aged at room temperature for 18 hours, after which under ice cooling, a mixture of 0.5 g sodium thiosulfate pentahydrate and 15 g water was added dropwise to quench the reaction. The solution was combined with 100 g of toluene, 50 g of ethyl acetate, and 50 g of water. The organic layer was separated, washed with water, and concentrated in vacuum. This was followed by crystallization from hexane, filtration and drying, obtaining 13.5 g of the target compound, 4-cyclopentyloxyphenyl phenyl sulfoxide as white crystals. Yield 96%.

Provenance & Evidence