Hydrogen Peroxide → HCID 117666424, compound

Participants

Reaction Steps

In 770 g of acetic acid was dissolved 109.3 g of 4-[2-(2-methoxyethoxy)ethoxy]phenyl phenyl sulfide obtained in Synthesis Example 1-38. While the solution was maintained at an internal temperature of 30° C., 34.5 g of 35 wt % aqueous hydrogen peroxide was added dropwise. The reaction solution was aged at room temperature for 18 hours, after which under ice cooling, a mixture of 8.8 g sodium thiosulfate pentahydrate and 80 g water was added dropwise to quench the reaction. The solution was combined with 200 g of toluene, 200 g of ethyl acetate and 200 g of water. The organic layer was separated, washed with water, and concentrated in vacuum, obtaining 112.9 g of the target compound, 4-[2-(2-methoxyethoxy)ethoxy]phenyl phenyl sulfoxide as oily matter. Yield 92%.

Provenance & Evidence